Protocols for the use of cyproterone, medroxyprogesterone, and leuprolide in the treatment of paraphilia.

OBJECTIVE To propose a protocol for minimizing medical complications associated with the use of cyproterone, medroxyprogesterone, and depot leuprolide to treat paraphilia. METHOD Review of the relevant literature. RESULTS Certain patient populations should not be treated with these medications, and medical complications associated with each can be detected early and avoided. CONCLUSIONS For each drug, a series of screening tests prior to use and scheduled testing during use can minimize potential medical complications.